PepGuide — Evidence-Based Peptide Research Encyclopedia
An open-access peptide encyclopedia with peer-reviewed citations, primary-source links, and transparent separation between research and commercial availability.
PepGuide — Peptide Research Encyclopedia
The research-focused encyclopedia of peptides. Profiles connect mechanisms, evidence, safety context, and protocols to published sources. Commercial relationships are disclosed and kept separate from editorial evidence. No paywalls.
700+ peptide profiles · Primary-source links · Evidence-stage context · Transparent disclosures
Why PepGuide?
- Editorially separated. Commercial availability never determines coverage, claims, or scientific conclusions. Relationships are disclosed where they appear.
- Cited. Research claims link to scientific or regulatory sources so readers can inspect the underlying evidence.
- Maintained. Profiles carry update and citation context when those fields are available.
- Research-first. We distinguish between in vitro, animal, and human data. We report limitations. We note when evidence is preliminary.
Read more about our editorial standards and methodology.
Browse by Category
🔥 GLP-1 & Metabolic (68)
Semaglutide, Tirzepatide, Retatrutide, AOD-9604, 5-Amino-1MQ — GLP-1 agonists and metabolic regulators.
📈 Growth Hormone (22)
Sermorelin, CJC-1295, Ipamorelin, GHRP-2/6, MK-677 — GHRH analogs and secretagogues.
🩹 Healing & Repair (35)
BPC-157, TB-500, GHK-Cu, KPV — angiogenesis, cell migration, and tissue regeneration.
⏳ Longevity & Anti-Aging (22)
Epithalon, MOTS-c, Humanin, SS-31 — telomerase, mitochondria, and geroprotection.
🧠 Cognitive & Nootropic (48)
Semax, Selank, Dihexa, Cerebrolysin, Cortagen — nootropic and neuroprotective peptides.
⚡ Sexual Health & Hormones (27)
PT-141, Kisspeptin-10, Gonadorelin, Oxytocin — melanocortin agonists and reproductive health.
✨ Skin & Cosmetic (38)
GHK-Cu, Argireline, SNAP-8, Matrixyl — signal peptides, copper peptides, and collagen stimulators.
🔬 Russian Bioregulators (18)
The complete Khavinson family — organ-specific short peptides for gene expression modulation.
🛡️ Antimicrobial & Immune (21)
LL-37, Thymosin Alpha-1, KPV, Defensins — host defense peptides and immunomodulators.
💊 Pain & Inflammation (9)
BPC-157, DSIP, ARA-290, VIP — analgesic and anti-inflammatory peptides.
❤️ Cardiovascular (10)
Cardiogen, ANP, BNP, Apelin — cardiac repair and vascular health research.
💪 Muscle & Performance (4)
Ostarine, LGD-4033, YK-11 — SARMs and muscle-performance research compounds.
🦴 Bone & Joint (4)
Abaloparatide, ACE-031, PTH analogs — bone density and joint research.
🔎 Cancer Research (10)
Angiostatin, Endostatin, EP100 — anti-angiogenic and tumor-targeting peptides.
🧪 Other Research Peptides (29)
Specialized research peptides, novel compounds, and emerging areas of study.
Latest Research
March 2026 Updates
365 peptide profiles, 8 research guides, 16 categories, and regulatory news.
Research Alerts
Active clinical trials: SELECT, SURMOUNT, TRIUMPH, REDEFINE, EMANATE, and more.
Changelog
Complete log of every change to the wiki.
Most Popular Peptides
| Peptide | Category | Why It's Notable |
|---|---|---|
| BPC-157 | Healing & Repair | 100+ preclinical studies; broadest tissue-repair evidence base of any research peptide |
| TB-500 | Healing & Repair | Cardiac progenitor cell activation; fundamental role in cell migration |
| Semaglutide | Metabolic | FDA-approved GLP-1 agonist; SELECT trial cardiovascular outcomes data |
| GHK-Cu | Longevity / Skin | Modulates 4,000+ genes; the most broadly active tripeptide known |
| Epithalon | Longevity | Telomerase activation; Khavinson's flagship longevity peptide |
| Ipamorelin | Growth Hormone | Cleanest GH secretagogue profile; selective ghrelin mimetic |
| Semax | Cognitive | BDNF upregulation; Russia's most-prescribed nootropic peptide |
| Thymosin Alpha-1 | Immune | 28-amino acid thymic peptide; approved in 35+ countries |
| PT-141 | Sexual Health | FDA-approved (Vyleesi); melanocortin-based sexual function |
| Tirzepatide | Metabolic | Dual GIP/GLP-1 agonist; 22.5% weight loss in SURMOUNT-1 |
Essential Research Guides
| Guide | Description |
|---|---|
| BPC-157 Complete Guide | All forms, routes, doses, and research |
| TB-500 Complete Guide | Thymosin beta-4 research consolidated |
| GLP-1 Agonist Comparison | Head-to-head efficacy and side effect data |
| Peptide Stacking Guide | Research-based combinations for every goal |
| Peptide Storage & Reconstitution | Stability evidence, diluent compatibility, expiration terms, and quality records |
| Peptide Administration Guide | Product-specific evidence for injectable, nasal, oral, mucosal, and topical routes |
| Peptide Injection Safety | Verify the exact product, device instructions, contamination controls, and response plan |
| Insulin Syringe Scales | Distinguish U-100 concentration, barrel capacity, graduations, and medication-error risks |
| How to Read Peptide Research | Appraise study design, outcomes, bias, statistics, safety, and claim boundaries |
| Peptide Research Databases | Verify identity, literature, human trials, approval status, and product claims |
| Peptide Purity Testing | Audit HPLC, LC-MS, assay, microbiological controls, and lot-linked COA evidence |
Getting Started
Peptides are short chains of amino acids (typically 2-50 residues) that act as signaling molecules in the body. Each profile in this wiki includes:
- Mechanism of action — how the peptide works at the molecular level
- Research summary — key findings from preclinical and clinical studies
- Quick reference table — molecular weight, sequence, CAS number, half-life
- Scientific references — links to published papers on PubMed
- Citation count — number of peer-reviewed sources backing each profile
Browse the full A-Z index, follow a question-led research path, or use the search bar above to find a peptide by name.
About PepGuide
PepGuide is an educational resource with a documented separation between research and commercial availability. Read about our mission and editorial standards, our research methodology, our sourcing and commercial policy, or learn how to read peptide research.
Disclaimer
This wiki is an educational resource for research purposes only. Content is based on published scientific literature and does not constitute medical advice. Peptides discussed here are research compounds — consult qualified professionals for any health-related decisions. Commercial relationships are disclosed and do not determine editorial coverage or conclusions.