Cardiovascular Peptides
Research peptides that influence cardiac function, vascular health, blood pressure regulation, and cardiovascular tissue repair.
Cardiovascular Peptides
This category covers peptides researched for their effects on the heart, blood vessels, and circulatory system. Cardiovascular peptides act through mechanisms including angiogenesis, cardiac tissue repair, blood pressure regulation, endothelial function, and metabolic modulation.
Complete Peptide Directory
Natriuretic & Blood Pressure Peptides
| Peptide | Description | Primary Mechanism |
|---|---|---|
| ANP | Atrial natriuretic peptide that regulates blood pressure and fluid balance | NPR-A receptor; natriuresis, vasodilation, RAAS suppression |
| BNP | B-type natriuretic peptide; cardiac biomarker and vasodilator | NPR-A receptor; ventricular volume/pressure regulation; heart failure marker |
| Angiotensin 1-7 | Counter-regulatory peptide in the renin-angiotensin system | Mas receptor; vasodilation, anti-fibrotic, anti-inflammatory |
| Bradykinin | Vasoactive peptide that mediates vasodilation and inflammation | B2 receptor; NO release, vasodilation, vascular permeability |
Vascular & Endothelial Peptides
| Peptide | Description | Primary Mechanism |
|---|---|---|
| Apelin | Endogenous peptide that regulates cardiovascular homeostasis and angiogenesis | APJ receptor; positive inotrope, vasodilator, angiogenic factor |
| Adrenomedullin | Vasodilatory peptide with cardioprotective and angiogenic properties | CRLR/RAMP2 receptor; vasodilation, angiogenesis, organ protection |
| Urotensin-2 | Most potent vasoconstrictor peptide known; cardiovascular remodeling | UT receptor; vasoconstriction, cardiac hypertrophy, vascular remodeling |
| VIP | Vasoactive intestinal peptide with vasodilatory and anti-inflammatory effects | VPAC receptors; coronary vasodilation, pulmonary hypertension research |
| VIP Analog | Modified VIP with enhanced stability for cardiovascular applications | VPAC receptor agonist with improved pharmacokinetics |
Cardiac Repair & Protection
| Peptide | Description | Primary Mechanism |
|---|---|---|
| Cardiogen | Short peptide bioregulator targeting cardiac tissue gene expression | Myocardial regeneration; age-related cardiac decline; Khavinson research |
| CAR Peptide | Cardiac-homing peptide that targets injured myocardium | Selective accumulation in ischemic cardiac tissue; drug delivery vehicle |
| Urocortin | CRF-related peptide with potent cardioprotective effects | CRF2 receptor; inotropic support, cardioprotection during ischemia |
| C-Peptide | Proinsulin cleavage product with vascular and neuroprotective effects | GPR146 receptor; endothelial NO release; microvascular function |
Common Research Themes
Natriuretic Peptide System: ANP and BNP are both endogenous regulators of blood pressure and fluid balance, but originate from different cardiac chambers (atria vs. ventricles) and serve as distinct clinical biomarkers.
RAAS Counter-Regulation: Angiotensin 1-7 acts as a natural counterbalance to the vasoconstrictive and pro-fibrotic effects of angiotensin II, representing a protective arm of the renin-angiotensin system.
Cardiac Regeneration: Cardiogen and CAR Peptide represent two distinct approaches — Cardiogen targets gene expression in cardiac tissue through bioregulatory mechanisms, while CAR Peptide serves as a homing peptide to deliver therapeutics to injured myocardium.
Angiogenesis: Apelin, Adrenomedullin, and VIP all promote new blood vessel formation through distinct pathways, making them relevant to ischemic tissue research and vascular repair.
Getting Started
If you are new to this category, we recommend starting with BPC-157 — the most widely studied peptide in this category with broad cytoprotective effects across cardiovascular and vascular systems. From there, explore related peptides through the See Also sections on each page to build a comprehensive understanding of the research landscape.
Cosmetic & Topical Peptides — Complete Guide
Comprehensive reference for all cosmetic peptides used in topical formulations — signal peptides, neuromuscular inhibitors, copper peptides, carrier peptides, and pigmentation modulators.
Pain & Nociception Peptides
Research peptides involved in pain signaling, nociceptive modulation, analgesic pathways, and neuroinflammatory pain conditions.