Longevity & Anti-Aging Peptides
Research peptides studied for telomerase activation, mitochondrial protection, bioregulation, and lifespan extension in preclinical models.
Longevity & Anti-Aging Peptides
This category covers peptides researched for their potential to slow biological aging through telomere maintenance, mitochondrial optimization, gene expression modulation, and cellular stress resistance. Many originate from endogenous signaling molecules or Russian bioregulator research programs.
Complete Peptide Directory
| Peptide | Description | Primary Mechanism |
|---|---|---|
| Epithalon | Tetrapeptide telomerase activator with demonstrated lifespan extension in animal models | Activates telomerase; modulates pineal gland melatonin release |
| Epitalon Long Course | Extended-duration Epithalon protocol for sustained telomerase activation | Prolonged telomerase induction and circadian rhythm optimization |
| Epitalon Nasal | Intranasal Epithalon formulation for enhanced CNS delivery | Epithalon mechanisms with improved blood-brain barrier penetration |
| Epithalon Acetate | Acetate salt form of Epithalon with improved solubility | Telomerase activation with enhanced formulation stability |
| N-Acetyl Epithalon Amidate | Enhanced Epithalon with N-acetyl and amide modifications | Improved BBB penetration; telomerase activation; neuronal differentiation |
| Short-Chain Epithalon | Truncated Epithalon variant for targeted applications | Telomerase modulation with distinct pharmacokinetic profile |
| FOXO4-DRI | Cell-penetrating peptide that disrupts FOXO4-p53 interaction in senescent cells | Induces selective apoptosis of senescent cells (senolytic) |
| Humanin | Mitochondrial-derived peptide with broad cytoprotective effects | Anti-apoptotic signaling via STAT3 and IGFBP-3 binding |
| Humanin Analog S14G | Enhanced humanin variant with 1000x greater potency | Neuroprotection, metabolic regulation with improved receptor binding |
| MOTS-c | Mitochondrial-derived peptide that regulates metabolic homeostasis | Activates AMPK; regulates folate-methionine cycle; exercise mimetic |
| MOTS-c S6K1 | MOTS-c variant targeting the mTOR/S6K1 pathway | Metabolic regulation through mTOR signaling modulation |
| Klotho | Anti-aging protein that regulates phosphate metabolism and oxidative stress | FGF23 co-receptor; Wnt signaling modulation; mineral homeostasis |
| GDF-11 | Growth differentiation factor linked to tissue rejuvenation in parabiosis studies | TGF-beta superfamily signaling; muscle and neural stem cell activation |
| SS-31 (Elamipretide) | Mitochondria-targeted peptide that stabilizes the inner membrane | Cardiolipin stabilization; ATP production; ROS reduction |
| NAD+ | Essential coenzyme for cellular energy and sirtuin activation | Substrate for sirtuins and PARPs; supplemented as NMN/NR precursors |
| 5-Amino-1MQ | NNMT inhibitor that boosts NAD+ levels and fat metabolism | Inhibits nicotinamide N-methyltransferase; increases cellular NAD+ |
| 5-Amino-1MQ / NMN Longevity Formula | Combination formula targeting NAD+ metabolism from two angles | NNMT inhibition plus NAD+ precursor supplementation |
| Telomerase Peptide | Peptide designed to activate telomerase for telomere maintenance | Direct telomerase enzyme activation and telomere elongation |
| SIRT1 Activating Peptide | Peptide that activates sirtuin-1 deacetylase for longevity pathways | SIRT1 activation; DNA repair enhancement; metabolic optimization |
| Yamanaka Peptides | Peptide-based approach to cellular reprogramming inspired by Yamanaka factors | Partial cellular reprogramming without full dedifferentiation |
| Thymalin / Epithalon Combo | Combined thymic and pineal bioregulator protocol | Dual immune restoration and telomerase activation |
| Alpha-Ketoglutarate Peptide | Peptide conjugate of the TCA cycle intermediate alpha-ketoglutarate | TCA cycle optimization; epigenetic modulation; lifespan extension in models |
| Spermidine Peptide Interaction | Research on spermidine's interactions with peptide longevity pathways | Autophagy induction; histone acetylation modulation |
Common Research Themes
Mitochondrial Peptides: MOTS-c, Humanin, and SS-31 are all derived from or target mitochondria — the organelles most implicated in cellular aging. They address different aspects: energy metabolism (MOTS-c), cell survival signaling (Humanin), and membrane integrity (SS-31).
Telomere Maintenance: Epithalon and its enhanced variants are the primary telomerase-activating peptides, with animal studies showing measurable lifespan extension.
Senescent Cell Clearance: FOXO4-DRI represents the senolytic approach — selectively eliminating damaged cells that accumulate with age and drive chronic inflammation.
NAD+ Metabolism: 5-Amino-1MQ, NAD+, and the longevity formula target the age-related decline in NAD+ levels that impairs sirtuin activity and mitochondrial function.
Epigenetic Modulation: Several peptides (Yamanaka Peptides, Alpha-Ketoglutarate Peptide) work by modulating epigenetic marks that change during aging, potentially reversing aspects of the aging clock.
Getting Started
If you are new to this category, we recommend starting with Epithalon — the most studied anti-aging peptide with a unique telomerase-activating mechanism. From there, explore related peptides through the See Also sections on each page to build a comprehensive understanding of the research landscape.
Healing & Tissue Repair Peptides
Research peptides that promote wound healing, angiogenesis, cell migration, and tissue regeneration across musculoskeletal, gastrointestinal, and dermal systems.
Growth Hormone Secretagogue Peptides
Research peptides that stimulate natural growth hormone release through GHRH receptor and ghrelin receptor (GHS-R) pathways.