Cancer Research Peptides

Explore oncology research profiles and evidence guides by mechanism, research stage, safety context, and primary sources.

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Cell killing, tumor models, biomarker changes, early-phase safety, and improved survival are distinct evidence stages. Oncology claims require particular caution.

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FOXO4-DRIFOXO4-DRI is a D-retro-inverso senolytic peptide that selectively induces apoptosis in senescent cells by disrupting the FOXO4-p53 protein-protein intPNC-27A synthetic anticancer peptide that selectively targets and destroys cancer cells by binding to HDM2 on their surface, inducing membrane lysis while lAra 290ARA-290 (cibinetide) is a synthetic 11-amino acid peptide derived from the non-hematopoietic tissue-protective region of erythropoietin that selectiveAngiostatinAngiostatin is a 38 kDa endogenous angiogenesis inhibitor derived from plasminogen kringle domains 1-4. Discovered by Judah Folkman's laboratory in 19Beclin-1-Derived PeptidesBeclin-1-derived peptides are synthetic fragments of the essential autophagy regulator Beclin-1, designed to disrupt the inhibitory Beclin-1/BCL-2 intBombesin / Gastrin-Releasing Peptide (GRP)Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina). Its mammalian homolog, gastBuserelinBuserelin is a synthetic GnRH agonist with a D-Ser(tBu)6 substitution and C-terminal ethylamide modification, approximately 40x more potent than nativCAR PeptideCAR peptide is a cell-penetrating STAT3-inhibiting peptide with research applications in cancer, neuroinflammation, and autoimmune conditions, blockinEndostatinEndostatin is a 20 kDa C-terminal fragment of collagen XVIII and one of the most potent endogenous angiogenesis inhibitors known. Discovered by O'ReilEP-100EP-100 is a chimeric peptide conjugate consisting of an LHRH (luteinizing hormone-releasing hormone) targeting domain fused to a synthetic lytic peptiEpithalonEpithalon (Epitalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland extract Epithalamin, studied for its ability to activGonadorelinGonadorelin (GnRH) is a decapeptide gonadotropin-releasing hormone that stimulates LH and FSH release, with clinical applications in fertility assessmGV1001GV1001 is a 16-amino acid peptide derived from the active site of human telomerase reverse transcriptase (hTERT 611-626) developed as a cancer vaccineIGF-2IGF-2 (Insulin-like Growth Factor 2) is a 67 amino acid peptide hormone critical for fetal growth and development, regulated by genomic imprinting. ItKisspeptin-10Kisspeptin-10 is a synthetic decapeptide that activates the KISS1R (GPR54) receptor to modulate GnRH neuron signaling. It is researched for applicatioLanreotideA long-acting cyclic octapeptide somatostatin analog used in acromegaly and neuroendocrine tumors, given as a deep subcutaneous depot every 4 weeks.Leuprolide (Leuprorelin)Synthetic nonapeptide agonist of gonadotropin-releasing hormone that, given as a depot, suppresses sex-hormone production; used in prostate cancer, enMet-EnkephalinMet-enkephalin (YGGFM) is an endogenous opioid pentapeptide with dual roles as a delta/mu-opioid receptor agonist and opioid growth factor (OGF), with
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Cancer Research Peptides

Peptides under investigation for anti-cancer properties, spanning senolytic agents, anti-angiogenic factors, immune checkpoint modulators, and telomerase-targeting compounds.

<Callout type="info"> These peptides are in various stages of research. None should be considered cancer treatments. This information is for research reference only. </Callout>

Senolytic & Anti-Aging

Anti-Angiogenic

Immune Checkpoint & Immunotherapy

Telomerase & Telomere

Autophagy & Apoptosis

Antimicrobial Peptides with Anti-Cancer Properties

See Also